纳米白藜芦醇脂质体的物理化学稳定性研究

纳米载药脂质体的物理化学稳定性,是其实际应用中的关键问题。文章采用薄膜旋转蒸发法-超声法制备了白藜芦醇纳米脂质体（RES-Lip）,采用透射电子显微镜观察其微观形貌,并考察RES-Lip的物理化学稳定性。通过电导法测定了RES-Lip的相变温度（Tm）,及其在凝聚过程的凝聚速率常数（Kco）和表观活化能（Eco）;采用动态透析-紫外分光光度法,研究了温度和pH对RES-Lip降解的影响。结果表明,RES-Lip为球形囊泡结构,粒径小于100 nm;RES-Lip的相变温度为64℃;凝聚速率常数Kco随体系温度升高而升高;表观活化能Eco为86.056 kJ/mol;RES-Lip的降解符合一级动力学模型,降解的表观活化能Ea为59.3157 kJ/mol,降解过程是吸热、自发、熵增过程。本实验制备得到的RES-Lip在4℃、pH=7.40的条件下储存,稳定性较好。     

石墨烯玻璃透明薄膜加热特性

Graphene has become a research focus in recent years owing to its excellent characteristics, and glass is a commonly used material with high transparency and low cost. Graphene glass combines the excellent properties of both graphene and glass; graphene glass has not only high thermal conductivity, high electrical conductivity, and good surface hydrophobicity but also exhibits superior electrothermal conversion and wide-spectrum high-light-transmittance characteristics. Therefore, the study of graphene glass films is of theoretical value and practical significance. In this study, a high-purity glass-based (JGS1 quartz glass) multilayer graphene film was developed based on an atmospheric-pressure chemical vapor deposition (APCVD) method, and its electrical characteristics, light transmittance, and electrical heating characteristics were experimentally investigated in detail. The results show that graphene glass with different surface resistance values obtained through direct growth on a high-purity quartz glass substrate using the APCVD method, not only has excellent uniformity and quality, but also has considerably flat and high transmittance across the entire visible light region and exhibits excellent heating performance and fast response time. For graphene glass with a surface resistance of 1500 Ω·sq^-1, the light transmittance can reach 74%, and the saturation temperature can rise to 185 ℃ by applying a bias voltage of 40 V. In addition, when the resistance value of the graphene glass is 420 Ω·sq^-1, the graphene glass reaches a high saturation temperature of 325 ℃ in 40 s, and the corresponding heating rate can exceed 18 ℃·s^-1, achieving a significantly higher heating rate than other heating films at the same voltage. Compared with the polyethylene-terephthalate- (PET-) based and silicon-based graphene films obtained by the transfer, graphene glass has a higher saturation temperature, shorter thermal response time, and faster heating rate. Furthermore, graphene glass exhibits better heating cycle stability and longer-term heating stability at a constant voltage. In addition, an experiment using the graphene glass to thermally tune the wavelength of a vertical-cavity surface-emitting laser was conducted and gave good results. The position of the laser peak controlled by the graphene glass was red-shifted by 1.78 nm by applying a voltage of 20 V, and the wavelength tuning efficiency reached 0.059 nm·℃^-1. Compared with PET-based and silicon-based graphene films, the actual electrical heating capacity of graphene glass increased by 195%. These experimental findings demonstrate that graphene glass transparent films with excellent electric heating characteristics can be used in various transparent electric heating fields and have relatively wide application prospects.     

多相催化生物甘油选择性氧化制取1,3-二羟基丙酮的研究进展北大核心CSCD

1,3-二羟基丙酮(DHA)是一种重要的化工原料,广泛应用于医药、化妆品及食品等领域.通过催化选择性氧化甘油制备DHA是一条高效、经济的工艺路线,而催化剂的种类及反应方式被证明对DHA的产率有较大影响.因此,结合近些年来相关文献,系统阐述了热、光和电这3种催化反应方式在甘油氧化制取DHA上的研究进展,并重点介绍了热催化路径中所选用的催化剂、相关研究实例及反应机理.最后,对甘油制备DHA的多路径选择性氧化的研究前景进行了展望.     

PREPARATION AND CHARACTERIZATION OF SUPERPARAMAGNETIC FUNCTIONAL POLYMERIC MICROPARTICLES

Superparamagnetic poly(styrene-divinylbenzene-glycidyl methacrylate) (Pst-DVB-GMA) microparticles were prepared via a modified suspension polymerization process. A magnetic fluid was first prepared by a chemical co-precipitation method. Then magnetic microparticles were produced by mixing the monomers and the magnetic fluid with water in the presence of a stabilizer poly(vinyl pyrrolidone) (PVP) to form a suspension, and finally benzoyl peroxide was added to initiate the co-polymerization. The morphology and magnetic properties of the microparticles were examined by TEM and VSM. The spherically shaped microparticles, with a size range of 4 to 7 pm, showed distinct superparamagnetic characteristics. XRD was used to investigate the structure of the magnetite particles dispersed in the polymer matrix. The microparticles with epoxy groups on their surface can be applied directly to the seoaration of biomolecules.     

多层材料结构的界面裂纹尖端复应力强度因子

本文建立了一种多层材料复合结构的界面裂纹问题分析模型。当两种材料之间插入第三种薄层弹性材料,裂纹位于第三种材料与第一或第二种弹性材料的界面上,且插页材料3~#的厚度相对于裂纹尺寸或平面内其他尺寸很小时,可以得到该问题裂纹尖端的复应力强度因子通式。本文用有限元法对结果进行了数值验证,并进行了有关问题的讨论。     

中柱失效工况下单层组合框架受力理论分析

基于已有试验，本文提出了轴向弹簧和转动弹簧约束的组合框架简化计算模型，推导了在集中荷载作用下刚性、半刚性连接平面组合梁双跨钢框架移除中柱后的荷载-跨中挠度曲线计算公式，考虑了压拱效应和连接刚度的影响，将公式计算结果与试验结果进行对比证明了推导过程和计算公式的可靠性．在对比结果的基础上，根据已有试验和模拟结果对已有悬索阶段的计算公式进行修正，修正后的公式与试验结果吻合较好．     

A UNIVERSAL APPROACH FOR CONTINUOUS OR DISCRETE NONLINEAR PROGRAMMINGS WITH MULTIPLE VARIABLES AND CONSTRAINTS

IntroductionExtensive research works have been published for solving nonlinear mathematicprogramming problems.Nonetheless,it is still difficult to find an effective and universalapproach for general programming problems with multiple design variables and …     

应力波传播规律研究中的一种快速分析方法

本文提出了一种能快速、简便、直观地分析了应力波传播状况的方法。该方法利用可视化计算并绘制流前图，而后将其与动光弹条纹图相比较，进而利用所推导的应力波迭加分析式判断出物体边界或其内部的应力波迭加效果。文中对圆盘中的几个典型区域进行了实例分析。     

包含两类变量的离散变量桁架结构拓扑优化设计

建立了包含截面和拓扑两类变量的离散变量结构拓扑优化设计的数学模型,该模型考虑了截面变量与拓扑变量间的耦合关系,反映了拓扑优化问题的组合优化本质,可以较好地解决"极限应力"、"最优解的奇异性"等困扰结构拓外优化设计的问题．同时采用相对差商法进行离散变量桁架结构拓扑优化,直接求解包含两类变量的离散变量结构拓扑优化设计数学模型,收到了比较满意的效果．     

45钢柱壳膨胀断裂的应变率效应

采用前照明高速分幅照相技术拍摄到在爆轰加载下45钢柱壳表面裂纹生成、扩展及产物泄漏过程的清晰图像,较准确地测量了膨胀断裂的时间与应变。 45钢柱壳在炸药爆轰加载下,断裂应变随应变率的增加而增加,当应变率达到一定值,断裂应变随应变率的增加而降低,出现了动态断裂中的塑性峰现象。